OpenScience is an AI workbench for scientific research. You give it a goal, and it works through the research loop the way a capable collaborator would. It reads the papers that matter, forms a hypothesis, writes and runs code, runs experiments on real compute, queries the major scientific databases, and writes up the result. It runs as a workspace in your browser and works with any frontier or open-weight model from Anthropic, OpenAI, Google, and dozens of other providers, using your own API keys. No account is required.
It is model-agnostic, open source, and built to do real work in machine learning, biology, physics, and chemistry.
What it does
Runs the whole loop. Literature review, hypothesis, code, experiment, analysis, and write-up, in one continuous session.
Research agents. A research agent by default, plus biology, physics, and ml specialists, with critique and literature-review sub-agents and a read-only plan mode.
290+ skills. Training (DeepSpeed, PEFT, TRL), evaluation, dataset work, molecular and clinical biology, cheminformatics, papers and LaTeX, figures, and cloud compute (Modal, Tinker, and others).
Scientific databases as tools. UniProt, PDB, Ensembl, ChEMBL, PubChem, arXiv, OpenAlex, Semantic Scholar, and around 30 more, queryable directly by the agent.
A real workspace. A browser UI with a file tree, an editor, a terminal, session history, and inline rendering for molecules, structures, genomes, and plots.
Extensible. LSP integration, MCP servers, plugins, custom agents and commands, and a TypeScript SDK.
Install
Install with npm, then open the workspace:
npm install -g @synsci/openscience
openscience
The command is openscience, and it opens the workspace in your browser. The first time you run it, a short setup walks you through how to power the models — Atlas managed models, your own provider keys, or skip and start on the free demo models. If you would rather not install it globally, npx synsci does the same thing in a single step:
npx synsci
Platform binaries are also attached to GitHub Releases; see the changelog for what's new in each version.
Quickstart
Set an API key from any provider (ANTHROPIC_API_KEY, OPENAI_API_KEY, GEMINI_API_KEY, and so on) and start the workspace:
export ANTHROPIC_API_KEY=sk-ant-...
openscience
openscience opens the workspace in your browser. Your keys stay on your machine and requests go straight to the provider. You can also run openscience keys add to store a key from the terminal, add keys from the Credentials panel, and pick a model from the model selector. To open the workspace in a specific project:
openscience ~/code/my-project
Atlas
Atlas is Synthetic Sciences' managed platform. It gives you a curated set of frontier models billed from a prepaid wallet, so you do not need per-provider keys, plus a persistent research graph and cloud compute. OpenScience works with Atlas but never requires it.
openscience login # connect your Atlas account
openscience wallet # check your balance and top up
Bring-your-own-key usage is always free and is never gated — Atlas only meters the models it serves. Use openscience status to see what you are connected to, and openscience logout to disconnect.
How it works
OpenScience runs a local server that hosts the workspace UI, the agent runtime, and the tool layer. The agent plans with a research harness, calls tools (shell, editor, LSP, MCP servers, scientific connectors, and skills), and streams its work back to the browser. Models are routed per request, so you can switch between providers or run local models without changing anything else. Sessions, artifacts, and provenance are stored on disk and can be shared as links.
Path
Contents
backend/cli
The CLI, server, provider integrations, sessions, and skills
frontend/workspace
The browser workspace UI, served by the CLI
frontend/docs
The documentation and session-share site
tooling/sdk/js
The TypeScript SDK
tooling/plugin
The plugin runtime
Configuration
Global config lives in ~/.config/openscience/openscience.json. Project config lives in openscience.json or a .openscience/ directory at the repo root (schema). Custom agents, commands, tools, plugins, and themes load from those directories.
The agent is not sandboxed. The permission system keeps you aware of what the agent is doing; it is not an isolation boundary. Run inside a container or VM if you need isolation. Provider and synced credentials are filtered out of subprocess environments and redacted from output. To report a vulnerability, see SECURITY.md.
OpenScience is an independent project. It is not affiliated with, endorsed by, or sponsored by Anthropic. "Claude" is a trademark of Anthropic, PBC, used here only to describe compatibility.
